Ω76: A designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii

Drug resistance is a public health concern that threatens to undermine decades of medical progress. ESKAPE pathogens cause most nosocomial infections, and are frequently resistant to carbapenem antibiotics, usually leaving tigecycline and colistin as the last treatment options. However, increasing tigecycline resistance and colistin’s nephrotoxicity severely restrict use of these antibiotics. We have designed antimicrobial peptides using a maximum common subgraph approach. Our best peptide (Ω76) displayed high efficacy against carbapenem and tigecycline-resistant Acinetobacter baumannii in mice. Mice treated with repeated sublethal doses of Ω76 displayed no signs of chronic toxicity. Sublethal Ω76 doses co-administered alongside sublethal colistin doses displayed no additive toxicity. These results indicate that Ω76 can potentially supplement or replace colistin, especially where nephrotoxicity is a concern. To our knowledge, no other existing antibiotics occupy this clinical niche. Mechanistically, Ω76 adopts an α-helical structure in membranes, causing rapid membrane disruption, leakage, and bacterial death. The emergence of drug-resistant pathogens has proven to be a grave pu...

Revenue from the Sales of Carbon Graphite Bushings Market to Increase Exponentially During 2017 – 2025

A recent report by Persistence Market Research on ‘Carbon Graphite Bushings Market’ provides a detailed analysis on the industry size, revenue forecasts and geographical landscape pertaining to this business space. Additionally, the report highlights primary obstacles and latest growth trends accepted by key players that form a part of the competitive spectrum of this business. Bushing is one of the type of bearing also known as plain bearing, it is an independent part of the bearing which is implanted into housing of bearing surface for rotational application. There is various range of bushing available starting from simple sleeve bushing to complex style incorporating notches, grooves or metal reinforcing sleeves. The bushing is made up of material with high wear resistance, durable and resistant to corrosion and elevated temperature. Hence the materials such as Babbitt, bi-material, bronze, cast iron, graphite, jewels, and plastic are preferred for making a bush. Among all the types of bushings, carbon- graphite bushings are ideal above all due to the properties such as self-lubricating, high fatigue resistance, resistance to corrosion, excellent dimensional stability, low th...